Study shows surge of bad disease genes in Europeans - News - … MSN Canada News25 minutes ago A scan of all the mutations in the human gene map shows something surprising – people of European descent are evolving fast, and not for the better. The study finds ... Study shows surge of bad disease genes in Europe - One News … One News Page4 hours ago Study shows surge of bad disease genes in Europe ♦ A scan of all the mutations in the human gene map shows that in the past 5,000 years, European-Americans have ... Study shows surge of bad disease genes in Europeans A scan of all the mutations in the human gene map shows something surprising – people of European descent are evolving fast, and not for the better. The study finds that in the past 5,000 years, European-Americans have developed a huge batch of potentially harmful genetic mutations – many more than African-Americans. The study, published in the journal Nature, may help explain why so many people develop diseases even though they don’t have common genetic mutations. It can also help explain why different people have so many different reactions to the same drug, said Joshua Akey of the University of Washington in Seattle who led the study. It likely has to do with population explosion, Akey said. European populations expanded after the Ice Age ended and prosperous agricultural societies emerged. “The number of mutations that exist is directly attributable to the population growth that happened in the last 5,000 years,” Akey told NBC News. “The things that allowed us to go from millions to billions of has also been the same process that has been pumping in all these new mutations.” Akey and colleagues at genetics institutions across the country examined the gene sequences of more than 6,500 people – more than 4,200 European-Americans and 2,200 African-Americans. They were looking for small changes in the genetic code called single nucleotide variants – one-letter differences in the genetic code of A,C, T and G. They found “an enormous excess of rare variants” in the European-Americans. And 73 percent of these mutations only appeared in the human genome in the past 5,000 to 10,000 years. Most were mutations that are known to weaken proteins, Akey said, and most of these harmful mutations were also in the people of European descent. Now researchers are working to see which of these mutations might be associated with diseases. But many are in known disease-causing genes, such as the LAMC1 gene associated with premature ovarian failure, LRP1, which is linked with both Alzheimer’s disease and obesity and the CPE gene linked to hardening of the arteries. .