Scientists Find Cancer Drivers Hiding in a New Place
Just exactly where is this new place, why it is in mRNA. What is mRNA you ask?
Well it is an information carry molecule that tells the cells what type of protein to produce in the human body. Well why is this important you ask. Messenger RNA (mRNA) is in vaccines!!!
News & Information/In the News
In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA
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By Matthew Tontonoz Monday, August 27, 2018
Sloan Kettering Institute molecular biologist Christine Mayr
Christine Mayr is a member of the Cancer Biology and Genetics Program of the Sloan Kettering Institute.
Summary
Researchers at the Sloan Kettering Institute have found that changes in an information-carrying molecule called messenger RNA can inactivate tumor-suppressing proteins and thereby promote cancer. The findings pinpoint previously unknown drivers of the disease.
It’s important to note that mRNAs are a normal component of all cells and the specific ones discussed here are not involved in mRNA-based vaccines, like the one developed against SARS-CoV-2.
One Question.( If the mRNAs that they are referencing to aren't in the vaccines then where are they and what is the point of this discovery being made public? )
Most people think of cancer as a disease of disorderly DNA. Changes, or mutations, in the sequence of DNA alter the function of the proteins made from that DNA, leading to uncontrolled cell division.
But between DNA and proteins is another layer of information, called messenger RNA (mRNA), which serves as a crucial link between the two. New research suggests that mRNA itself may carry cancer-causing changes. And, because genetic tests don’t usually look at mRNA, those changes have so far gone undetected by cancer doctors.
“If you sequenced the DNA in cancer cells, you would not see these changes at all,” says Christine Mayr, a molecular biologist at the Sloan Kettering Institute who is the senior author of a new paper on the topic published today in Nature. “But these mRNA changes have the same ultimate effect as known cancer drivers in DNA, so we believe they may play a very important role.”
If you sequenced the DNA in cancer cells, you would not see these changes at all.
Christine Mayr- Molecular Biologist
In case you'd like to read the entire article
New findings from researchers at the Sloan Kettering Institute suggest that cancer causes may be lurking in the molecule that bridges DNA and protein.
www.mskcc.org